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The neurologic phenotype in SCA8 BAC expansion but not BAC Regulate strains shown the pathogenicity on the (CTG-CAG)n growth. Moreover, the expression of noncoding (CUG)n growth ATXN8OS transcripts and the invention of intranuclear polyglutamine inclusions instructed that SCA8 pathogenesis includes harmful attain-of-operate mechanisms at both of th